Diuretie activity of gossypetin isolated from hibiscus sabdariffa in rats

Gossypetin [3, 5, 7, 8, 3', 4'-hexahydroxy flavone] isolated from the flowers of Hibiscus sabdariffa has been tested for diuretic activity in rats. The parameters observed for each individual rat included body weight before and after test period, total urine volume [corrected for water intake during the test period], urine concentration of Na[+], K[+] and Cl[-]. The values of urine volume and cation excretion were increased with reference to saline control by Gossypetin [100 mg/kg of body weight]. Furosemide was used as a reference diuretic